Rhomboid Protease Dynamics and Lipid Interactions
نویسندگان
چکیده
منابع مشابه
Rhomboid protease dynamics and lipid interactions.
Intramembrane proteases, which cleave transmembrane (TM) helices, participate in numerous biological processes encompassing all branches of life. Several crystallographic structures of Escherichia coli GlpG rhomboid protease have been determined. In order to understand GlpG dynamics and lipid interactions in a native-like environment, we have examined the molecular dynamics of wild-type and mut...
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Structures of the prokaryotic homologue of rhomboid proteases reveal a core of six transmembrane helices, with the active-site residues residing in a hydrophilic cavity. The native environment of rhomboid protease is a lipid bilayer, yet all the structures determined thus far are in a nonnative detergent environment. There remains a possibility of structural artefacts arising from the use of de...
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The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome. Still, however, little is known about the components mediating ERAD of membrane proteins. Here we show that the evolutionary conserved rhomboid family protein RHBDL4 is a ubiquitin-dependent ER-resident intramembrane prote...
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The epidermal growth factor receptor (EGFR) has several functions in mammalian development and disease, particularly cancer. Most EGF ligands are synthesized as membrane-tethered precursors, and their proteolytic release activates signalling. In Drosophila, rhomboid intramembrane proteases catalyse the release of EGF-family ligands; however, in mammals this seems to be primarily achieved by ADA...
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The simulated lipid droplet contained 630 1-palmitoyl-2-oleoyl-3-phosphatidylcholine (POPC), 80 1-palmitoyl-3-phosphatidylcholine (denoted as lysoPC in the main article), 600 cholesterol (CHOL), 1600 cholesteryl oleate (CO), and 180 trioleate (TO) molecules. This molecular composition is similar to the average physiological composition seen in experiments [17]. The lipid droplet was constructed...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2008.12.017